In this issue:
  -  Is RA always preceded by a symptomatic phase of arthralgia?
  -  CV outcomes with low-dose glucocorticoids in RA
  -  Physical inactivity exacerbates inflammatory signalling in systemic lupus
  -  Impact of patient characteristics on disease activity cutoffs in axial SpA
  -  Effect of sex and age on biologic DMARD efficacy in axial SpA
  -  Escalation to second-line therapies in early RA: risk of becoming difficult-to-treat
  -  JAK inhibitors in difficult-to-treat RA
  -  CV safety of JAK inhibitors in RA
  -  RA and ischaemic stroke risk after AF
  -  Systemic JIA and adult-onset Still’s disease: the same disease
    
    
    
      
      
        
        
        
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